In the present study maize starch, tapioca starch, potato starch and soluble starch were used as a disintegrating agent and an antiadherent in Isoniazid as well as Diclofenac sodium tablets at concentration of 2, 4, 6% w/w. Properties of the granules prepared from various starches were evaluated for Moisture content, Bulk density, Tapped density, Carr’s index and Hausner’s ratio. The tablets were evaluated for thickness, weight variation, hardness, friability, disintegration time and dissolution profiles. The granules formulated using Maize starch showed the least Carr’s index, Hausner’s ratio, moisture content values. The results obtained indicate that among the granules prepared from all the starches in relation to their flowability, the granules prepared from maize starch possess the best flow property. Also, the disintegrants maize starch, tapioca starch, potato starch showed comparable results in Isoniazid as well as Diclofenac sodium tablets.
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